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1

Cyclopentanone ring-cleaved pleuromutilin derivatives

Dane M. Springer, Amy Bunker, Bing-Yu Luh, Margaret E. Sorenson, Jason T. Goodrich, Joanne J. Bronson, Kenneth DenBleyker, Thomas J. Dougherty, Joan Fung-Tomc

Journal:

European Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 475 KB

english, 2007

2

Fourth-generation cephalosporins

Joan C. Fung-Tomc

Journal:

Clinical Microbiology Newsletter

Année:

1997

Langue:

english

Fichier:

PDF, 794 KB

english, 1997

3

Synthesis and Antibacterial Activity of Dihydro-1,2-oxazine and 2-Pyrazoline Oxazolidinones: Novel Analogues of Linezolid.

Stan D'Andrea, Zhizhen Barbara Zheng, Kenneth DenBleyker, Joan C. Fung-Tomc, Hyekyung Yang, Junius Clark, Dennis Taylor, Joanne Bronson

Journal:

Année:

2005

Fichier:

PDF, 22 KB

2005

4

Novel C-acylated triazole derivatives of ravuconazole, an azole antifungal agent

Oak Kim, Yunhui Zhang, John Wichtowski, Stella Huang, Joan Fung-Tomc, Joanne Bronson, Yasutsugu Ueda

Journal:

Journal of Heterocyclic Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 366 KB

english, 2008

5

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

Lawrence B. Snyder, Zhaoxing Meng, Robert Mate, Stanley V. D’Andrea, Anne Marinier, Claude A. Quesnelle, Patrice Gill, Kenneth L. DenBleyker, Joan C. Fung-Tomc, MaryBeth Frosco, Alain Martel, John F.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 332 KB

english, 2004

6

Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid

Stan D’Andrea, Zhizhen Barbara Zheng, Kenneth DenBleyker, Joan C. Fung-Tomc, Hyekyung Yang, Junius Clark, Dennis Taylor, Joanne Bronson

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 241 KB

english, 2005

7

Synthesis and in vitro antibacterial activity of new semi-synthetic noviosylcoumarin antibiotics: chemical modification at the C-3′ ester

Yasutsugu Ueda, Julia M. Chuang, Joan Fung-Tomc, R.A. Partyka

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1994

Langue:

english

Fichier:

PDF, 400 KB

english, 1994

8

Synthesis and anti-MRSA Activity of Novel Cephalosporin Derivatives

Stan V. D'Andrea, Daniel Bonner, Joanne J. Bronson, Junius Clark, Ken Denbleyker, Joan Fung-Tomc, Shelley E. Hoeft, Thomas W. Hudyma, John D. Matiskella, Raymond F. Miller, Peter F. Misco, Michael Puc

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 212 KB

english, 2000

9

In vitro activity of ravuconazole against Zygomycetes, Scedosporium and Fusarium isolates

B. Minassian, E. Huczko, T. Washo, D. Bonner, J. Fung-Tomc

Journal:

Clinical Microbiology and Infection

Année:

2003

Langue:

english

Fichier:

PDF, 47 KB

english, 2003

10

Susceptibility of bacterial isolates to β-lactam antibiotics from U.S. clinical trials over a 5-year period

Robert E. Kessler, Joan Fung-Tomc

Journal:

The American Journal of Medicine

Année:

1996

Langue:

english

Fichier:

PDF, 758 KB

english, 1996

11

In vitro antifungal activity of BMS-207147 and itraconazole against yeast strains that are non-susceptible to fluconazole

Joan C Fung-Tomc, Theodore C White, Beatrice Minassian, Elizabeth Huczko, Daniel P Bonner

Journal:

Diagnostic Microbiology and Infectious Disease

Année:

1999

Langue:

english

Fichier:

PDF, 138 KB

english, 1999

12

Susceptibility of united states clinical trial isolates to cefprozil and cefaclor

Robert E. Kessler, Joan C. Fung-Tomc

Journal:

Diagnostic Microbiology and Infectious Disease

Année:

1994

Langue:

english

Fichier:

PDF, 320 KB

english, 1994

13

Susceptibility of bacterial isolates to gatifloxacin and ciprofloxacin from clinical trials 1997–1998

E Huczko, B Conetta, D Bonner, L Valera, T Stickle, A Macko, J Fung-Tomc

Journal:

International Journal of Antimicrobial Agents

Année:

2000

Langue:

english

Fichier:

PDF, 72 KB

english, 2000

14

Comparative killing kinetics of the novel des-fluoro(6) quinolone BMS-284756, fluoroquinolones, vancomycin and β-lactams

E. Gradelski, L. Valera, B. Kolek, D. Bonner, J. Fung-Tomc

Journal:

International Journal of Antimicrobial Agents

Année:

2001

Langue:

english

Fichier:

PDF, 134 KB

english, 2001

15

Activity of gatifloxacin and ciprofloxacin in combination with other antimicrobial agents

E. Gradelski, B. Kolek, D.P. Bonner, L. Valera, B. Minassian, J. Fung-Tomc

Journal:

International Journal of Antimicrobial Agents

Année:

2001

Langue:

english

Fichier:

PDF, 68 KB

english, 2001

16

Activity of gatifloxacin against strains resistant to ofloxacin and ciprofloxacin and its ability to select for less susceptible bacterial variants

J Fung-Tomc, E Gradelski, E Huczko, B Minassian, D.P Bonner

Journal:

International Journal of Antimicrobial Agents

Année:

2001

Langue:

english

Fichier:

PDF, 66 KB

english, 2001

17

Synergistic activity of the novel des-fluoro(6) quinolone, garenoxacin (BMS-284756), in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species

J.C Fung-Tomc, E Gradelski, L Valera, E Huczko, D.P Bonner

Journal:

International Journal of Antimicrobial Agents

Année:

2002

Langue:

english

Fichier:

PDF, 83 KB

english, 2002

18

Synthesis and antibacterial activity of some novel 6-methyl- and 6-propenyl-substituted carbapenems

Mastalerz, Harold, Menard, Marcel, Ruediger, Edward, Fung-Tomc, Joan

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 822 KB

english, 1992

19

Fluoronaphthyridines and -quinolones as antibacterial agents. 5. Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones

Di Cesare, P., Bouzard, D., Essiz, M., Jacquet, J. P., Ledoussal, B., Kiechel, J. R., Remuzon, P., Kessler, R. E., Fung-Tomc, J., Desiderio, J.

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 1.20 MB

english, 1992

20

Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted derivatives

Remuzon, P., Bouzard, D., Di Cesare, P., Essiz, M., Jacquet, J. P., Kiechel, J. R., Ledoussal, B., Kessler, R. E., Fung-Tomc, J.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 867 KB

english, 1991

21

Detection of microbial antigens in spinal fluid and blood

Fung-Tomc, Joan C.

Journal:

Clinical Immunology Newsletter

Année:

1986

Langue:

english

Fichier:

PDF, 446 KB

english, 1986

22

Correlation of in vitro and in vivo resistance development to antimicrobial agents

Fung-Tomc, Joan C.

Journal:

Antimicrobic Newsletter

Année:

1990

Langue:

english

Fichier:

PDF, 893 KB

english, 1990

23

Fluoronaphthyridines as antibacterial agents. 4. Synthesis and structure-activity relationships of 5-substituted 6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids

Bouzard, D., Di Cesare, P., Essiz, M., Jacquet, J. P., Ledoussal, B., Remuzon, P., Kessler, R. E., Fung-Tomc, J.

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 819 KB

english, 1992

24

An examination of O-2-isocephems as orally absorbable antibiotics

Mastalerz, Harold, Menard, Marcel, Vinet, Vivianne, Desiderio, James, Fung-Tomc, Joan, Kessler, Robert, Tsai, Yuan

Journal:

Journal of Medicinal Chemistry

Année:

1988

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1988

25

Recent developments in pradimicin-benanomicin and triazole antibiotics

Fung-Tomc, Joan C, Bonner, Daniel P

Journal:

Expert Opinion on Investigational Drugs

Année:

1997

Langue:

english

Fichier:

PDF, 365 KB

english, 1997

26

In vitro antibacterial spectrum of a new broad-spectrum 8-methoxy fluoroquinolone, gatifloxacin

Fung-Tomc, J., Minassian, B., Kolek, B., Washo, T., Huczko, E., Bonner, D.

Journal:

Journal of Antimicrobial Chemotherapy

Année:

2000

Langue:

english

Fichier:

PDF, 75 KB

english, 2000

27

β-Lactamase parameters of heterogeneously and homogeneously methicillin-resistant Staphylococcus aureus

GRADELSKI, ELIZABETH, HUCZKO, ELIZABETH, KESSLER, ROBERT E., BONNER, DANIEL P., FUNG-TOMC, JOAN

Journal:

Journal of Antimicrobial Chemotherapy

Année:

1993

Langue:

english

Fichier:

PDF, 165 KB

english, 1993

28

Patents on β-lactam antibacterials: January 1999 to March 2001

Fung-Tomc, Joan, Kim, Oak K

Journal:

Expert Opinion on Therapeutic Patents

Année:

2001

Langue:

english

Fichier:

PDF, 160 KB

english, 2001

29

Correlation between Genotype and Phenotypic Categorization of Staphylococci Based on Methicillin Susceptibility and Resistance

Gradelski, E., Valera, L., Aleksunes, L., Bonner, D., Fung-Tomc, J.

Journal:

Journal of Clinical Microbiology

Année:

2001

Langue:

english

Fichier:

PDF, 51 KB

english, 2001

30

Synergistic Activities of Gatifloxacin in Combination with Other Antimicrobial Agents against Pseudomonas aeruginosa and Related Species

Gradelski, E., Valera, L., Bonner, D., Fung-Tomc, J.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2001

Langue:

english

Fichier:

PDF, 54 KB

english, 2001

31

Antibacterial activities of cefprozil compared with those of 13 oral cephems and 3 macrolides

Fung-Tomc, J. C., Huczko, E., Stickle, T., Minassian, B., Kolek, B., Denbleyker, K., Bonner, D., Kessler, R.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1995

Langue:

english

Fichier:

PDF, 166 KB

english, 1995

32

Activity of the novel des-fluoro(6) quinolone BMS-284756 against methicillin-susceptible and -resistant staphylococci

Journal:

Journal of Antimicrobial Chemotherapy

Année:

2001

Langue:

english

Fichier:

PDF, 53 KB

english, 2001

33

In Vitro and In Vivo Activities of a Novel Cephalosporin, BMS-247243, against Organisms other than Staphylococci

Clark, J., Fung-Tomc, J. C., Minassian, B., Tsai, Y.-H., Yang, H., Huczko, E., Kolek, B., Chaniewski, S., Ferraro, C., Drain, R., Gradelski, E., Bonner, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2002

Langue:

english

Fichier:

PDF, 64 KB

english, 2002

34

In vitro activities of cefepime alone and with amikacin against aminoglycoside-resistant gram-negative bacteria.

Fung-Tomc, J, Huczko, E, Kolek, B, Thater, C, Kessler, R E

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1991

Langue:

english

Fichier:

PDF, 499 KB

english, 1991

35

Ciprofloxacin-induced, low-level resistance to structurally unrelated antibiotics in Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus.

Fung-Tomc, J, Kolek, B, Bonner, D P

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1993

Langue:

english

Fichier:

PDF, 1.52 MB

english, 1993

36

Activity of quinolones in the Ames Salmonella TA102 mutagenicity test and other bacterial genotoxicity assays.

Mamber, S W, Kolek, B, Brookshire, K W, Bonner, D P, Fung-Tomc, J

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1993

Langue:

english

Fichier:

PDF, 1.31 MB

english, 1993

37

In vitro antifungal and fungicidal spectra of a new pradimicin derivative, BMS-181184

Fung-Tomc, J. C., Minassian, B., Huczko, E., Kolek, B., Bonner, D. P., Kessler, R. E.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1995

Langue:

english

Fichier:

PDF, 240 KB

english, 1995

38

In vitro activity of BMS-181139, a new carbapenem with potent antipseudomonal activity

Kessler, R. E., Fung-Tomc, J., Kolek, B., Minassian, B., Huczko, E., Gradelski, E., Bonner, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1995

Langue:

english

Fichier:

PDF, 224 KB

english, 1995

39

Activity of cefepime against ceftazidime- and cefotaxime-resistant gram-negative bacteria and its relationship to beta-lactamase levels.

Fung-Tomc, J, Dougherty, T J, DeOrio, F J, Simich-Jacobson, V, Kessler, R E

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1989

Langue:

english

Fichier:

PDF, 1017 KB

english, 1989

40

In vitro and in vivo antibacterial activities of BMY 40062, a new fluoronaphthyridone.

Fung-Tomc, J, Desiderio, J V, Tsai, Y H, Warr, G, Kessler, R E

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1989

Langue:

english

Fichier:

PDF, 1.47 MB

english, 1989

41

Comparative Killing Rates of Fluoroquinolones and Cell Wall-Active Agents

Fung-Tomc, J. C., Gradelski, E., Valera, L., Kolek, B., Bonner, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2000

Langue:

english

Fichier:

PDF, 83 KB

english, 2000

42

In Vitro and In Vivo Activities of a Novel Cephalosporin, BMS-247243, against Methicillin-Resistant and -Susceptible Staphylococci

Fung-Tomc, J. C., Clark, J., Minassian, B., Pucci, M., Tsai, Y.-H., Gradelski, E., Lamb, L., Medina, I., Huczko, E., Kolek, B., Chaniewski, S., Ferraro, C., Washo, T., Bonner, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2002

Langue:

english

Fichier:

PDF, 92 KB

english, 2002

43

In vitro and in vivo evaluations of a new broad-spectrum oral cephalosporin, BMY-28232, and its prodrug esters.

Tomatsu, K, Masuyoshi, S, Hirano, M, Kawaguchi, H, Oki, T, Fung-Tomc, J, Desiderio, J V, Kessler, R E

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1989

Langue:

english

Fichier:

PDF, 1.12 MB

english, 1989

44

Structure-activity relationships of carbapenems that determine their dependence on porin protein D2 for activity against Pseudomonas aeruginosa

Fung-Tomc, J. C., Huczko, E., Banville, J., Menard, M., Kolek, B., Gradelski, E., Kessler, R. E., Bonner, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1995

Langue:

english

Fichier:

PDF, 218 KB

english, 1995

45

Activity of carbapenem BMS-181139 against Pseudomonas aeruginosa is not dependent on porin protein D2

Fung-Tomc, J. C., Gradelski, E., Kolek, B., Minassian, B., Pucci, M., Kessler, R. E., Bonner, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1995

Langue:

english

Fichier:

PDF, 242 KB

english, 1995

46

Antimicrobial Evaluation of Nocathiacins, a Thiazole Peptide Class of Antibiotics

Pucci, M. J., Bronson, J. J., Barrett, J. F., DenBleyker, K. L., Discotto, L. F., Fung-Tomc, J. C., Ueda, Y.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2004

Langue:

english

Fichier:

PDF, 138 KB

english, 2004

47

Antibacterial Spectrum of a Novel Des-Fluoro(6) Quinolone, BMS-284756

Fung-Tomc, J. C., Minassian, B., Kolek, B., Huczko, E., Aleksunes, L., Stickle, T., Washo, T., Gradelski, E., Valera, L., Bonner, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2000

Langue:

english

Fichier:

PDF, 79 KB

english, 2000

48

Frequency of in vitro resistance of Pseudomonas aeruginosa to cefepime, ceftazidime, and cefotaxime.

Fung-Tomc, J, Huczko, E, Pearce, M, Kessler, R E

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1988

Langue:

english

Fichier:

PDF, 520 KB

english, 1988

49

Development of resistance in Pseudomonas aeruginosa to broad-spectrum cephalosporins via step-wise mutations

Gradelski, E., Fung-Tomc, J., Huczko, E., Kessler, R. E.

Journal:

Journal of Antimicrobial Chemotherapy

Année:

1993

Langue:

english

Fichier:

PDF, 317 KB

english, 1993

50

ChemInform Abstract: Fluoronaphthyridines and Quinolones as Antibacterial Agents. Part 2. Synthesis and Structure-Activity Relationships of New 1-tert-Butyl 7-Substituted Derivatives.

BOUZARD, D., DI CESARE, P., ESSIZ, M., JACQUET, J. P., KIECHEL, J. R., REMUZON, P., WEBER, A., OKI, T., MASUYOSHI, M., KESSLER, R. E., FUNG-TOMC, J., DESIDERIO, J.

Journal:

Année:

1990

Fichier:

PDF, 223 KB

1990